Side A
For research portal users
Browse compounds, targets, and the mechanistic evidence — a read-optimised surface for the wider research community.
Open the research portalNon-stimulant repurposing, evidence-first.
A drug repurposing platform for non-stimulant ADHD therapeutics. Deterministic target scoring against eight ADHD-relevant classes, a knowledge graph over the mechanistic literature, and a licensing pipeline.
The pipeline for novel ADHD non-stimulants is thin. New chemical entities take a decade and a billion dollars, and mostly fail — the field can't wait, and it doesn't have to. Repurposing existing compounds against ADHD-relevant mechanisms is the fastest way to expand treatment options. The existing literature already contains most of what's needed to prioritise them.
Repose combines mechanism-aware target scoring — deterministic, explainable, updatable — with a curated knowledge graph and a licensing surface that connects promising candidates to pharma partners. The goal isn't to speculate; it's to hand off ranked, evidence-backed candidates to the teams who can take them into trial.
Eight ADHD-relevant mechanistic classes — the target space where a repurposed compound has real chance of translating.
Deterministic, explainable scoring against each target class — every rank ties back to its mechanistic evidence.
A knowledge graph over the mechanistic literature — compounds, targets, pathways, and outcomes, all connected and searchable.
Connect promising candidates to pharma partners with a licensing pipeline built into the platform.
The research portal is for exploring compounds and evidence. The analyst workbench is for deep analysis and licensing prep. Both are live.
Browse compounds, targets, and the mechanistic evidence — a read-optimised surface for the wider research community.
Open the research portalDeep analysis, knowledge-graph traversal, and licensing preparation — the working surface for analysts and partnership teams.
Open the workbenchRepose is one of the research tools built inside the Synapse Spark Foundation. Everything we make is part of the same mission — understanding neurodivergent minds and supporting the researchers advancing the science.
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